Question

is a substitution mutation harmful to an organism? (1 point)
yes, all mutations are harmful to organisms.
it depends on whether the resulting amino acid of the codon has changed.
no, substitution mutations are never harmful because they are silent.
substitution mutations are not a type of mutation.

Explanation:

Substitution mutations can have different effects. If the resulting amino acid changes, it may be harmful (e.g., in sickle - cell anemia). If it doesn't (silent mutation), it may not be. So it depends on the amino - acid change.

Answer:

It depends on whether the resulting amino acid of the codon has changed.