Question

a researcher wants to create a mouse model for a disease, to allow her team to study possible therapies. the disease is known to be caused by a small deletion that removes a certain gene. which type of mouse would be the best choice for this purpose? multiple choice tissue - specific gene knockout mutant derived by traditional forward genetics screen knockout mouse knockin mouse conditional knockout mouse activated by a drug

Explanation:

A knockout mouse has a gene that is completely inactivated or "knocked - out". Since the disease is caused by a gene deletion, a knockout mouse would mimic this genetic state best for studying therapies. A tissue - specific gene knockout only inactivates a gene in certain tissues, not globally as needed here. A mutant from a forward genetics screen is more for identifying genes involved in a phenotype rather than creating a specific gene - deleted model. A knockin mouse inserts a new gene rather than deleting one. A conditional knockout activated by a drug has more control over when the gene is inactivated and is not the most straightforward for a simple gene - deletion disease model.

Answer:

C. Knockout mouse