Question

rapidly progressive glomerulonephritis associated with goodpasture’s syndrome is a classic example of which one of the following mechanisms of glomerular injury? nephritis associated with activation of the alternative complement pathway nephritis caused by antibodies against planted non - glomerular antigens circulating immune - complex nephritis antiglomerular basement - membrane antibody nephritis

Explanation:

Goodpasture’s syndrome is characterized by the presence of antibodies against the glomerular basement membrane (GBM). Rapidly progressive glomerulonephritis in Goodpasture’s syndrome is due to antiglomerular basement - membrane antibodies attacking the GBM, leading to glomerular injury. The other options: activation of the alternative complement pathway is not the main mechanism here; antibodies against 'planted' non - glomerular antigens is not related; and circulating immune - complex nephritis is caused by immune complexes in the circulation, not by anti - GBM antibodies.

Answer:

D. antiglomerular basement - membrane antibody nephritis