Question

question
which of the following compounds inhibits pyruvate dehydrogenase via feedback inhibition?
answer
amp
coenzyme a
pyruvate
nadh
i dont know yet

Explanation:

Pyruvate dehydrogenase is inhibited by its products. NADH is a product of the pyruvate dehydrogenase - catalyzed reaction. High levels of NADH indicate that the cell has sufficient energy (as NADH is involved in ATP production via the electron - transport chain). So, NADH can inhibit pyruvate dehydrogenase through feedback inhibition.
AMP is an indicator of low energy (as it is formed from ATP breakdown), and it usually activates enzymes involved in energy - generating pathways. Coenzyme A is a substrate for the pyruvate dehydrogenase reaction (pyruvate + NAD+ + CoA - SH → acetyl - CoA+ NADH + H+). Pyruvate is the substrate of the pyruvate dehydrogenase reaction.

Answer:

NADH