Question

question 3 (mandatory) (10 points)
listen
list the cpk isoenzymes:

question 4 (mandatory) (10 points)
listen
what is the definitive test for pernicious anemia?

Explanation:

Creatine phosphokinase (CPK) has three isoenzymes. CPK - BB (brain type) is mainly found in the brain and some other tissues. CPK - MB (muscle - brain type) is significant in cardiac muscle. CPK - MM (muscle type) is the major form in skeletal muscle. For pernicious anemia, the Schilling test is definitive. It assesses vitamin B12 absorption. First, radioactive vitamin B12 is given orally. Then, urine is collected to measure the amount of excreted radioactive B12. If absorption is impaired (as in pernicious anemia due to lack of intrinsic factor), the excretion is low. After intrinsic factor is given along with radioactive B12 (in the second part of the test), if it's pernicious anemia (intrinsic - factor - deficiency), the excretion of radioactive B12 in urine will increase.

Answer:

Question 3: CPK - BB (brain type), CPK - MB (muscle - brain type), CPK - MM (muscle type).
Question 4: The Schilling test.