Question

which issue is related to long - term marijuana use?
brain damage
difficulty thinking
mood swings
altered senses

Explanation:

Long - term marijuana use can affect brain development and function. Brain damage is a more serious and long - lasting consequence compared to the other options which are more likely to be short - term or less severe in the context of long - term use. Difficulty thinking, mood swings, and altered senses can occur with marijuana use, but brain damage is a more significant issue related to long - term use as it can have more profound and lasting impacts on the central nervous system.

Answer:

brain damage