Question

which of the following is an inherited disease characterized by destruction of ach - secreting and gaba - secreting neurons in the basal nuclei causing difficulty controlling movements?
huntingtons disease
schizophrenia
alzheimers disease
parkinsons disease
senile dementia

Explanation:

Huntington's disease is an inherited disorder. It causes the degeneration of neurons (including ACh - secreting and GABA - secreting neurons in the basal nuclei). This leads to motor control problems such as involuntary movements, difficulty with balance and coordination.
Schizophrenia is mainly a mental disorder with symptoms like hallucinations, delusions, disorganized thinking, etc., not primarily a movement disorder due to basal nuclei neuron destruction.
Alzheimer's disease and senile dementia are mainly associated with cognitive decline (memory loss, decline in thinking skills) rather than the specific type of neuron destruction in the basal nuclei described here. Parkinson's disease is due to loss of dopamine - producing neurons in the substantia nigra (a part related to the basal ganglia circuit), with symptoms like tremors, bradykinesia, rigidity.

Answer:

Huntington's disease