Question

question 48

a pharmacy technician should recognize that which of the following medications is included on the niosh list of hazardous drugs due to its carcinogenic potential?

• atorvastatin (lipitor)
• cyclophosphamide (cytoxan)
• lisinopril (zestril)
• metformin (glucophage)

Explanation:

Identify NIOSH criteria

Using the Hazardous Drugs knowledge point
The National Institute for Occupational Safety and Health (NIOSH) defines hazardous drugs based on criteria including carcinogenicity, teratogenicity, developmental toxicity, reproductive toxicity, organ toxicity at low doses, and genotoxicity.

Evaluate the options

• Atorvastatin (Lipitor) is a lipid-lowering HMG-CoA reductase inhibitor and is not classified as a hazardous drug by NIOSH.
• Cyclophosphamide (Cytoxan) is an alkylating antineoplastic agent. It is a well-known carcinogen, mutagen, and teratogen, and is classified as a Group 1 hazardous drug by NIOSH.
• Lisinopril (Zestril) is an ACE inhibitor used for hypertension and is not on the NIOSH hazardous drug list.
• Metformin (Glucophage) is a biguanide oral hypoglycemic agent and is not classified as a hazardous drug by NIOSH.

Answer:

• Atorvastatin (Lipitor)
• Cyclophosphamide (Cytoxan) (Correct answer)
• Lisinopril (Zestril)
• Metformin (Glucophage)