Question

ige is implicated in the pathogenesis of:
extrinsic asthma
adult respiratory distress syndrome(ards)
goodpastures syndrome
hypersensitivity pneumonitis

Explanation:

Extrinsic asthma is a type of allergic asthma. IgE - mediated hypersensitivity reactions play a key role in its pathogenesis. In extrinsic asthma, allergens trigger the production of IgE antibodies, which then bind to mast cells and basophils. When the allergen is re - encountered, it cross - links the IgE on these cells, leading to the release of inflammatory mediators like histamine, leukotrienes, etc., which cause the asthmatic symptoms.

Adult Respiratory Distress Syndrome (ARDS) is mainly related to non - IgE - mediated mechanisms such as inflammation due to sepsis, trauma, etc. Goodpasture's syndrome is an autoimmune disease mediated by IgG antibodies against basement membrane antigens. Hypersensitivity pneumonitis is a type III or IV hypersensitivity reaction, not primarily mediated by IgE.

Answer:

A. Extrinsic asthma