Question

to help prevent fatigue on long trips:
get plenty of rest before you start out
drive faster to decrease total drive time
drive at night when there is less traffic

Explanation:

To prevent fatigue on long trips, getting enough rest before starting is a safe and effective method. Driving faster increases accident risk, and driving at night can worsen fatigue due to reduced visibility and circadian rhythm factors. So the correct option is the first one.

Answer:

get plenty of rest before you start out