Question

which might indicate to a doctor that there is an issue with someones body chemistry?
sugar in the blood
sugar in the urine
water in the urine
water in the blood

Explanation:

Normally, the kidneys reabsorb glucose (sugar) from the filtrate back into the bloodstream. When there is an issue like diabetes (where blood sugar levels are too high), the kidneys can't reabsorb all the glucose, and it spills into the urine. Blood normally has some sugar (glucose is the main energy source), urine normally has some water (as it's a main component of urine for waste excretion), and blood has water (as blood is mostly water with cells and solutes). So sugar in urine is an abnormal sign related to body chemistry (glucose metabolism).

Answer:

sugar in the urine