Question

us district courts hear federal cases involving
state and local issues.
civil and state issues.
civil and criminal issues.
criminal and international issues.

Explanation:

US District Courts are general - jurisdiction federal trial courts. They have the authority to hear both civil cases (such as disputes between private parties over contracts, torts etc.) and criminal cases (where the federal government prosecutes individuals for violating federal laws). State and local issues are mainly dealt with by state and local courts. International issues in a federal context might be more specialized (e.g., in some appellate or specialized federal courts for certain international trade - related federal laws, but not the main focus of District Courts). Civil and state is an incorrect combination as state issues are not the main federal court (District Court) domain.

Answer:

civil and criminal issues.