Question

a species of frog exhibits two varieties of eye color - black and yellow. you notice that most of the frogs have black eyes. however, when frogs are separated by sex, the majority of frogs with yellow eyes are males. you begin to suspect that eye color is sex - linked. which of the following will help you differentiate whether the locus for eye color is sex - linked or on an autosome?
a cross between heterozygous females and hemizygous, yellow - eyed males.
a cross between a yellow - eyed female and a black - eyed male will produce only black - eyed females and only yellow - eyed males.
a cross between a black - eyed female and a yellow - eyed male will result in only black - eyed offspring, regardless of sex.
a cross between yellow - eyed males and yellow - eyed females will produce only yellow - eyed offspring.

Explanation:

If eye - color is sex - linked, the inheritance pattern will be different compared to autosomal inheritance. For a sex - linked trait (assuming it is on the X - chromosome), a cross between heterozygous females (\(X^{A}X^{a}\)) and hemizygous, yellow - eyed males (\(X^{a}Y\)) will have different offspring ratios depending on sex. If it is autosomal, the sex of the offspring will not play a role in the inheritance pattern in the same way.

Answer:

A cross between heterozygous females and hemizygous, yellow - eyed males will produce only yellow - eyed males.