select the correct answer.

neurofibromatosis, a genetic disease caused by mutation on the nf1 gene, follows an autosomal dominant pattern of inheritance. the diagram shows that the father carries two copies of the defective gene and the mother is unaffected. what percentage of offspring will have neurofibromatosis?

autosomal dominant inheritance
affected
r r

normal
r r

0%
25%
50%
100%

Question

select the correct answer.

neurofibromatosis, a genetic disease caused by mutation on the nf1 gene, follows an autosomal dominant pattern of inheritance. the diagram shows that the father carries two copies of the defective gene and the mother is unaffected. what percentage of offspring will have neurofibromatosis?

autosomal dominant inheritance
affected
r r

normal
r r

0%
25%
50%
100%

Accepted Answer

{ "quality": "clear", "question_count": 1, "skills_matched": [ "step_cot", "multiple_choice_formatter", "explain_then_answer", "quick" ], "needs_drawing": false, "concepts_used": [], "new_concepts": [ "Autosomal Dominant Inheritance", "Punnett Square Analysis" ], "current_concepts": [ "Autosomal Dominant Inheritance", "Punnett Square Analysis", "Genetics" ] } ## Identify parental genotypes $$ \begin{aligned} &\text{Father (Affected, homozygous dominant): } RR \ &\text{Mother (Normal, homozygous recessive): } rr \end{aligned} $$ ## Determine offspring genotypes $$ \begin{aligned} &RR \times rr \implies 100\% \text{ of offspring will be } Rr \end{aligned} $$ ## Calculate percentage of affected offspring $$ \begin{aligned} &\text{Since } R \text{ is dominant, } Rr \text{ individuals are affected.} \ &\text{Percentage affected} = 100\% \end{aligned} $$

0%

25%

50%

100%

{ "subject": "Natural Science", "question_type": "Multiple Choice", "knowledge_point": [ "Natural Science", "Biology", "Autosomal Dominant Inheritance" ] }

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QUESTION IMAGE

Question

Explanation:

Identify parental genotypes

Determine offspring genotypes

Calculate percentage of affected offspring

Answer: