Question

select the correct answer.
chronic myeloid leukemia (cml) is a genetic disorder associated with the philadelphia chromosome. the philadelphia chromosome is a mutation in
chromosome 22. part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a
malignancy. what type of mutation occurs in the philadelphia chromosome?
a. duplication
b. insertion
c. inversion
d. substitution
e. translocation

Explanation:

Translocation is a type of chromosomal mutation where a segment of one chromosome is transferred to another non - homologous chromosome. In Chronic Myeloid Leukemia (CML), the Philadelphia chromosome is formed due to a reciprocal translocation between chromosome 9 and chromosome 22. This translocation brings together two genes (BCR from chromosome 22 and ABL from chromosome 9), leading to the formation of a fusion gene (BCR - ABL) which causes the malignancy.

Answer:

E. translocation