Question

question 1 1 pts

the above is a pedigree for a paternally imprinted gene, ube3a, found on chromosome 15 and associated with the condition known as angelman syndrome. for individual iii - 2, indicate whether the allele for the ube3a gene inherited from i - 1 is expressed in their somatic cells and gametes

expressed in gametes

expressed in both

imprinted in both

expressed in somatic cells

Explanation:

Imprinting is an epigenetic phenomenon. Paternally imprinted genes are silenced when inherited from the father. Individual III - 2 inherits the allele from I - 1 (a female, so not the paternal source in terms of imprinting context here). But for imprinted genes, in somatic cells, the imprinting status is maintained. However, in gametes, the imprint is reset. Since it's a paternally imprinted gene, the allele from I - 1 (assuming I - 1 is female, so not the paternal imprinting source here, but more importantly, in somatic cells, the non - paternal (maternal - like in this case as I - 1 is female) allele is expressed. In gametes, the imprint is reset, so the allele could be expressed in gametes. But wait, no - for paternally imprinted genes: in somatic cells, the maternal allele is expressed (since paternal is imprinted). III - 2 gets allele from I - 1 (assuming I - 1 is female, so maternal source). So in somatic cells, it's expressed. In gametes, the imprint is reset. But the question is about the allele inherited from I - 1. In somatic cells, it is expressed (because for paternally imprinted genes, maternal alleles are expressed in somatic cells). In gametes, when gametes are formed, the imprint is reset. But the allele itself (the one from I - 1) can be expressed in gametes (because the resetting occurs, and it's not imprinted in gametes in the same way as in somatic cells for the individual's own gamete - making process). Wait no - actually, imprinting in somatic cells: for paternally imprinted gene UBE3A, in somatic cells, only the maternal allele is expressed. III - 2's allele from I - 1 (assuming I - 1 is the maternal - line ancestor here). So in somatic cells, it is expressed. In gametes, when an individual makes gametes, the imprint is reset. So the allele (the one from I - 1) can be expressed in gametes (because the resetting allows for potential expression depending on the new imprinting in the next generation, but for the gamete itself (the cell), the gene can be expressed as the imprint is reset during gametogenesis).

Answer:

Expressed in both