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Question
progeria is a rare genetic condition in which children age rapidly, showing symptoms such as hair loss, growth delays, and stiff joints early in life. it is caused by a single - letter mutation in the lmna gene, where a cytosine changes to a thymine. this mutation leads to the production of an abnormal protein called progerin, which damages cells and accelerates aging processes. what kind of mutation causes the disease progeria? hint: is it a substitution, insertion, or deletion
The problem states that in the LMNA gene, a cytosine changes to a thymine. In genetics, when one nucleotide base is replaced by another, it is a substitution mutation. Insertion would be adding a base, and deletion would be removing a base. Since here it's a replacement (cytosine to thymine), it's substitution.
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Substitution mutation.