Question

compared to small cells, large cells have more trouble *
dividing.
producing daughter cells.
storing needed materials and waste products.
moving needed materials in and waste products out.

Explanation:

Large cells have a lower surface area-to-volume ratio. This ratio limits the efficiency of moving materials (nutrients, oxygen) into the cell and waste products out, as the surface area (for exchange) does not increase as fast as the volume (which requires more exchange). Dividing, producing daughter cells, and storing materials are not the primary issues compared to transport efficiency.

Answer:

dividing.