Question

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parkinsons disease, an example of a basal nuclei problem, typically strikes people in their fifties and sixties (actor michael j. fox is an unlucky exception who developed it around age 30). it results from a degeneration of specific neurons in the substantia nigra of the midbrain, which normally supply (1 ) to the basal nuclei. the dopamine - deprived basal nuclei, which help regulate voluntary motor activity, become overactive, causing symptoms of the disease. afflicted individuals have a persistent tremor at rest (exhibited by head nodding and a \pill - rolling\ movement of the fingers), a forward - bent walking posture and shuffling gait, and a stiff (2. ) expression. in addition, they have trouble initiating movement or getting their muscles going.
the cause of parkinsons disease is still unknown. the drug l - dopa, which is converted to dopamine in the brain, helps alleviate some of the symptoms. however, l - dopa is not a cure, and as more and more (3. ) die, it becomes ineffective. it also has undesirable side effects: severe nausea, dizziness, and, in some, liver damage. in 2015, the fda approved two new forms of l - dopa, rytary™ and duopa™, which are extended - release versions of existing drugs. both medications allow for more consistent dopamine levels and better control of symptoms.
deep - brain (thalamic) stimulation via implanted electrodes alleviates (4. ), but the procedure is risky and expensive. more promising are intrabrain transplants of embryonic substantia nigra tissue, genetically engineered adult nigral cells, or dopamine - producing cells from fetal pigs, all these have produced some regression of disease symptoms. however, the use of (5 ) tissue is controversial and riddled with ethical and legal roadblocks

1. fetal 2. dopamine 3. facial 4. neurons 5. tremors

1. neurons 2. tremors 3. fetal 4. dopamine 5. facial

1. tremors 2. fetal 3. dopamine 4. facial 5. neurons

1. dopamine 2 facial 3. neurons 4. tremors 5. fetal

1 facial 2. neurons 3 tremors 4. fetal 5. dopamine

Explanation:

Parkinson's disease is due to degeneration of neurons in substantia nigra that supply dopamine to basal nuclei. Symptoms include a stiff facial expression. As neurons die, L - dopa becomes ineffective. Deep - brain stimulation alleviates tremors and use of fetal tissue is controversial.

Answer:

1. dopamine
2. facial
3. neurons
4. tremors
5. fetal