Question

which of the following is a progressive, degenerative disorder that affects upper and lower motor neurons causing skeletal muscle atrophy?
paralysis
multiple sclerosis
cerebral palsy
amyotrophic lateral sclerosis
stroke

Explanation:

• Paralysis is a loss of muscle function, not specifically a progressive degenerative disorder affecting motor neurons.
• Multiple sclerosis is an autoimmune disease affecting the central nervous system's myelin, not primarily motor neurons causing skeletal muscle atrophy in this way.
• Cerebral palsy is a group of disorders affecting movement and posture, usually due to brain damage in early development, not a progressive degenerative disorder of motor neurons.
• Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative disorder that affects upper and lower motor neurons, leading to skeletal muscle atrophy.
• Stroke is a sudden event (ischemic or hemorrhagic) affecting blood supply to the brain, not a progressive degenerative disorder of motor neurons as described.

Answer:

amyotrophic lateral sclerosis