Question

the total number of subjects in a phase i study is generally: a) 20 to 80. b) several hundred. c) several thousand. d) 1 million.

Explanation:

Phase I studies are the first stage of clinical trials in humans. They mainly focus on evaluating safety, pharmacokinetics, and pharmacodynamics. The sample size is relatively small. Usually, it involves 20 - 80 healthy volunteers or patients. Larger sample sizes (several hundred, several thousand, 1 million) are for later - stage clinical trials (Phase II, Phase III, etc.) which focus on efficacy, side - effect monitoring in a larger population, etc.

Answer:

A. 20 to 80.