Question

given the cascade of events leading to ischemia - produced brain damage, it has been suggested that __________ antagonists administered immediately after a stroke might reduce the subsequent development of brain damage. acetylcholinesterase dopamine gaba serotonin glutamate

Explanation:

When there is ischemia - produced brain damage (such as in a stroke), excessive glutamate release occurs. Glutamate over - activates glutamate receptors (especially NMDA receptors), leading to excitotoxicity. Excitotoxicity is a major mechanism of neuronal damage in ischemic stroke. By using glutamate antagonists, the over - activation of glutamate receptors can be blocked, potentially reducing the subsequent development of brain damage.
Acetylcholinesterase is related to the breakdown of acetylcholine, dopamine and serotonin are neurotransmitters with different functions (not directly related to the main excitotoxic mechanism in ischemic stroke as much as glutamate), and GABA is an inhibitory neurotransmitter (but its antagonists would not be beneficial in reducing stroke - induced damage in the context of excitotoxicity).

Answer:

glutamate