Question

as discussed in class, which of the following patterns of necrosis is observed microscopically in the liver lobule associated with acetaminophen (tylenol) toxicity?
centrizonal necrosis
peripheral zonal necrosis
pan-lobular necrosis
focal necrosis

Explanation:

Acetaminophen (Tylenol) toxicity typically causes centrizonal (centrilobular) necrosis in the liver lobule. This is because the centrilobular hepatocytes are more susceptible to the toxic metabolites of acetaminophen, especially when glutathione stores are depleted. Peripheral zonal necrosis is not associated with acetaminophen; pan - lobular is seen in severe cases or other toxins like acute viral hepatitis in some contexts but not typical for acetaminophen initially; focal necrosis is more localized and not the pattern for acetaminophen - induced liver injury.

Answer:

A. Centrizonal necrosis