Question

blood clotting
type of feedback (circle one):
positive(+) or
negative (-)
hemophilia is a genetic disorder that affects the blood’s ability to clot properly due to a deficiency in specific clotting factors. how does this deficiency impact the feedback loop involved in the blood clotting process?
a. the absence of clotting factors leads to reduced activation of thrombin, leading to reduced clot formation.
b. hemophilia causes overproduction of platelets, leading to excessive clotting.
c. the deficiency in clotting factors accelerates the positive feedback loop, allowing for rapid clotting despite injury.
d. hemophilia does not affect the feedback loop; it only impacts the speed of clot formation.

frayer model of feedback loops
definition (in your own words) \tillustration that represents the word
examples \tnegative feedback loop \tnon-examples (or the opposite of...)

Explanation:

• Option A: Hemophilia is due to clotting factor deficiency. Clotting factors are needed for thrombin activation (part of the blood clotting positive feedback loop). Less clotting factors mean less thrombin activation, so less clot formation. This matches the disorder's effect.
• Option B: Hemophilia does not cause overproduction of platelets; it's about clotting factors, so B is wrong.
• Option C: A deficiency in clotting factors would slow, not accelerate, the positive feedback loop for clotting, so C is wrong.
• Option D: Hemophilia does affect the feedback loop (by reducing the factors needed for it) and not just the speed; it impacts the ability to clot, so D is wrong.

Answer:

A. The absence of clotting factors leads to reduced activation of thrombin, leading to reduced clot formation.