Question

which are used during preclinical trials to test the effects of drugs on live tissue?

human beings
plants
living organisms
bacteria cells

Explanation:

Define preclinical trials

Preclinical trials involve testing experimental drugs in vitro (cell cultures, isolated tissues) and in vivo (animal models) to assess safety and biological activity before human testing.

Evaluate the options

• Human beings: Tested during clinical trials, not preclinical.
• Plants: Not used to model human physiological drug effects.
• Living organisms: Represents animal models (in vivo testing) used to observe systemic drug effects on live tissue.
• Bacteria cells: Used for mutagenicity assays (e.g., Ames test) but do not represent complex live tissue systems.

Select the best fit

"Living organisms" (such as mice, rats, or rabbits) are the primary subjects used during preclinical in vivo testing to evaluate drug effects on live tissue systems.

Answer:

• Human beings
• Plants
• Living organisms (Correct answer)
• Bacteria cells