Question

which issue is related to long - term heroin use?
pleasure
depression
hypoxia
mood swings

Explanation:

Long - term heroin use can cause many psychological and physical problems. Heroin is a depressant. While initial use may cause pleasure, long - term use disrupts the brain's chemical balance. Depression is a common long - term consequence due to changes in neurotransmitter systems like dopamine and serotonin. Hypoxia is not a typical long - term issue directly related to heroin use. Mood swings can occur but depression is a more well - known long - term effect.

Answer:

B. depression