Question

which of the following test is definitive for pernicious anemia?
a) mma
b) schilling test
c) hypersegmented polymorphonuclear neutrophils
d) bone marrow iron stain

Explanation:

Pernicious anemia is a type of megaloblastic anemia caused by vitamin B12 deficiency due to lack of intrinsic factor. The Schilling test is used to assess vitamin B12 absorption. MMA (methylmalonic acid) levels can be elevated in B12 deficiency but is not specific to pernicious anemia. Hypersegmented polymorphonuclear neutrophils are a morphological finding in megaloblastic anemia (including pernicious anemia) but not a definitive test. Bone marrow iron stain is used to assess iron stores (for iron - deficiency anemia etc., not for pernicious anemia).

Answer:

B. Schilling test