Question

which effect leads to substance addiction when a person continues to smoke?
multiple choice
a low or irregular heart rate causes one to smoke in an effort to regulate heart rhythm
irritability and anxiety causes an unpleasant experience leading individuals to smoke to alleviate those feelings
nicotine creating a natural high acts as an endorphin, leaving individuals to crave more
increased sensitivity of neurons in response to nicotine leads to cravings

Explanation:

When a person continues to smoke, withdrawal symptoms like irritability and anxiety occur. These are unpleasant, so individuals smoke to relieve them, which can lead to addiction.

Answer:

irritability and anxiety causes an unpleasant experience leading individuals to smoke to alleviate those feelings