Question

question 30 (mandatory) (2 points) listen a 54 - year - old man with rapidly progressive dementia has a brain biopsy which shows diffusely distributed vacuoles and gliosis in the gray matter without inflammation. the white matter was unremarkable. the most likely diagnosis is: progressive multifocal leukoencephalopathy rabies jakob - creutzfeldt disease toxoplasmosis

Explanation:

Jakob - Creutzfeldt disease is a prion disease characterized by rapidly progressive dementia. Brain biopsy shows spongiform changes (diffusely distributed vacuoles) and gliosis in the gray matter without inflammation. Progressive Multifocal Leukoencephalopathy mainly affects white matter. Rabies has characteristic Negri bodies and inflammation. Toxoplasmosis is a parasitic infection with different histological features.

Answer:

Jakob - Creutzfeldt disease