Question

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which of the following mechanisms best explains how glucocorticoids can lead to hyperglycemia?
○ glucocorticoids stimulate gluconeogenesis in the liver.
○ glucocorticoids increase insulin production by the pancreas.
○ glucocorticoids enhance glucose uptake by muscle cells.
○ glucocorticoids decrease glycogen breakdown in the liver.

Explanation:

Glucocorticoids promote gluconeogenesis (new glucose production) in the liver, increasing blood glucose levels. The other options are incorrect: they do not increase insulin production (insulin lowers glucose), do not enhance muscle glucose uptake (they reduce it), and do not decrease liver glycogen breakdown (they increase it). Thus, stimulating gluconeogenesis is the key mechanism for hyperglycemia.

Answer:

Glucocorticoids stimulate gluconeogenesis in the liver.