Question

in preparing a cell sample for karyotyping, when are the chromosomes most visible?
a prophase
b metaphase
c anaphase
d telophase

Explanation:

During metaphase of cell division, chromosomes are maximally condensed. They align at the equatorial plane of the cell. This condensation and alignment make them most distinct and visible under a microscope, which is ideal for karyotyping (the process of pairing and ordering all the chromosomes of an organism). In prophase, chromosomes start to condense but are not as distinct as in metaphase. In anaphase, sister chromatids separate and move towards opposite poles, which may cause some distortion in their appearance for clear karyotyping. In telophase, chromosomes start to de - condense.

Answer:

B. Metaphase