Question

part 2
wild-type sequence:
atgtgccctttg...
individual 1:
atggccctttg...
what type of mutation does individual 1 have? select all that apply.
☐ missense
☐ nonsense
☐ silent
☐ frameshift
☐ insertion
☐ deletion

Explanation:

1. Compare the wild - type sequence (ATGTGCCCTTTG...) and Individual 1's sequence (ATGGCCCTTTG...). We can see that the 'T' at the third position (after 'ATG') in the wild - type is removed in Individual 1's sequence.
2. A deletion mutation is defined as the loss of one or more nucleotides from a DNA sequence. In this case, one nucleotide ('T') is deleted.
3. A frameshift mutation is caused by insertions or deletions of nucleotides that are not in multiples of three, which changes the reading frame. Here, the deletion of one nucleotide will cause a frameshift.
4. A missense mutation changes one amino acid to another, a nonsense mutation introduces a stop codon, and a silent mutation changes a codon but not the amino acid, and an insertion adds nucleotides. None of these other mutation types fit here.

Answer:

deletion, frameshift