Question

modifications of blood stem cells are
○ germ-line changes, so they can be passed on to offspring.
○ germ-line changes, so they will not be passed on to offspring.
○ somatic changes, so they can be passed on to offspring.
○ somatic changes, so they will not be passed on to offspring.

Explanation:

Blood stem cells are somatic cells. Somatic cell changes are not passed to offspring as they don't contribute genetic material to reproductive cells (germ - line cells). Germ - line changes occur in cells that give rise to gametes (sperm and eggs) and can be inherited. Since blood stem cells are somatic, their modifications won't be passed on.

Answer:

somatic changes, so they will not be passed on to offspring.