Question

many different types of mutations can occur within the body. cystic fibrosis is a genetic disorder that is caused by different mutations within the cftr gene. one mutation in the cftr gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence. which type of mutation causes this translation error that leads to cystic fibrosis?

○ silent
○ missense
○ nonsense
○ deletion

Explanation:

• A silent mutation does not change the amino - acid sequence (so it won't cause translation to end early).
• A missense mutation changes one amino - acid to another, but doesn't necessarily stop translation early.
• A deletion mutation is the loss of one or more nucleotides. While it can cause frameshifts (if not in multiples of 3), a nonsense mutation is more directly related to premature stop of translation.
• A nonsense mutation changes a codon for an amino - acid into a stop codon, which leads to premature termination of translation.

Answer:

nonsense