Question

list the genetic disorders found on chromosome 11.
what do you know about any of those disorders?

Explanation:

Chromosome 11 is associated with several genetic disorders. One well - known disorder is sickle cell anemia. Sickle cell anemia is an autosomal recessive disorder. The mutation occurs in the HBB gene (located on chromosome 11) which codes for the beta - globin subunit of hemoglobin. In sickle cell anemia, a single nucleotide substitution (a point mutation) changes the codon for glutamic acid (GAG) to valine (GTG). This leads to the production of abnormal hemoglobin (hemoglobin S). The abnormal hemoglobin causes red blood cells to take on a sickle - like shape, especially under low - oxygen conditions. These sickle - shaped cells can get stuck in blood vessels, leading to pain (sickle cell crises), organ damage (due to reduced blood flow), and anemia (as the sickle cells are more prone to destruction).

Answer:

• Genetic disorders on chromosome 11: Sickle cell anemia, Jacobsen syndrome (partial deletion of chromosome 11), and some cases of acute myeloid leukemia (associated with translocations involving chromosome 11).
• Information about sickle cell anemia: It is an autosomal - recessive disorder caused by a point mutation in the HBB gene on chromosome 11. The mutation leads to the production of abnormal hemoglobin (hemoglobin S), causing red blood cells to sickle. This results in pain (sickle cell crises), organ damage, and anemia.