Question

drag each tile to the correct location.

identify the types of mutations represented by the change in each dna sequence.

\

$$\begin{tabular}{|l|l|} \\hline \\textbf{change in nucleotide sequence} & \\textbf{type of mutation} \\\\ \\hline \\text{atgc} \ ightarrow \\text{atc} & \\\\ \\hline \\text{atgc} \ ightarrow \\text{attc} & \\\\ \\hline \\text{attcgc} \ ightarrow \\text{attcggc} & \\\\ \\hline \\text{acgt} \ ightarrow \\text{tgca} & \\\\ \\hline \\text{attg} \ ightarrow \\text{attgattg} & \\\\ \\hline \\text{attc (chromosome 1)} & \\\\ \\text{cgattc (chromosome 2)} \ ightarrow & \\\\ \\text{atcga (chromosome 1)} & \\\\ \\text{tcttc (chromosome 2)} & \\\\ \\hline \\end{tabular}$$

tiles:
inversion, insertion, deletion, substitution, translocation, duplication

Explanation:

Analyze sequence changes

• ATGC \(

ightarrow\) ATC: The nucleotide 'G' is removed.

• ATGC \(

ightarrow\) ATTC: The nucleotide 'G' is replaced by 'T'.

• ATTCGC \(

ightarrow\) ATTCGGC: An extra 'G' is added.

• ACGT \(

ightarrow\) TGCA: The sequence is reversed (inverted).

• ATTG \(

ightarrow\) ATTGATTG: The sequence 'ATTG' is repeated.

• ATTC (chromosome 1) and CGATTC (chromosome 2) \(

ightarrow\) ATCGA (chromosome 1) and TCTTC (chromosome 2): Segments are exchanged between non-homologous chromosomes.

Match with mutation types

• ATGC \(

ightarrow\) ATC: deletion

• ATGC \(

ightarrow\) ATTC: substitution

• ATTCGC \(

ightarrow\) ATTCGGC: insertion

• ACGT \(

ightarrow\) TGCA: inversion

• ATTG \(

ightarrow\) ATTGATTG: duplication

• Chromosome exchange: translocation

Answer:

Change in Nucleotide Sequence	Type of Mutation

| ATGC \(
ightarrow\) ATC | deletion |
| ATGC \(
ightarrow\) ATTC | substitution |
| ATTCGC \(
ightarrow\) ATTCGGC | insertion |
| ACGT \(
ightarrow\) TGCA | inversion |
| ATTG \(
ightarrow\) ATTGATTG | duplication |
| ATTC (chromosome 1)<br>CGATTC (chromosome 2)<br>\(
ightarrow\)<br>ATCGA (chromosome 1)<br>TCTTC (chromosome 2) | translocation |