Question

1. which disease was most responsible for the dramatic decline in native american populations during the colonization period?

a. yellow fever
b. cholera
c. smallpox
d. typhus

Explanation:

During the colonization period, Native Americans had no prior immunity to smallpox. European colonizers brought smallpox, and it spread rapidly among Native American populations, causing a massive decline. Yellow fever, cholera, and typhus were not as impactful in this population decline as smallpox.

Answer:

c. Smallpox