Question

10 select the correct word or phrase from each drop - down to accurately indicate when function of proteins is altered as a result of the disease or condition

1. osteogenesis imperfecta - weak or fragile bones caused by a genetic defect in collagen production
2. type ii diabetes mellitus - high blood glucose levels caused by decreased sensitivity to the hormone insulin
3. tetrodotoxin poisoning from a parrotfish exposure - paralyzes muscle due to binding of fast sodium channels
4. phenylketonuria - genetic mutation in an enzyme that catabolizes the amino acid phenylalanine
5. myasthenia gravis - antibodies bind to and attack the bodys own proteins
6. cardiac myopathy - induced by genetic alteration in abnormal myosin production
7. congenital ectodermal dysplasia - defect in desmosomes causing skin that easily separates from deeper layers

Explanation:

1. Osteogenesis imperfecta is due to a defect in collagen (a protein) production affecting bone structure.
2. In type II diabetes, insulin - a protein hormone - has reduced communication with cells.
3. Tetrodotoxin binding to sodium channels (proteins) affects muscle movement.
4. Phenylketonuria is caused by a mutation in an enzyme (a protein) that catalyzes a reaction.
5. In myasthenia gravis, antibodies attack self - proteins, a problem of protein recognition.
6. Cardiac myopathy due to abnormal myosin (a protein for muscle movement) production affects movement.
7. Congenital ectodermal dysplasia with a defect in desmosomes (protein - based cell adhesion structures) affects cell adhesion.

Answer:

1. Structure
2. Communication
3. Movement
4. Catalysis
5. Recognition
6. Movement
7. Cell Adhesion