Question

why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide - pair substitution missense mutation in the same protein?
a substitution missense mutation causes the protein to be shorter and thus non - functional.
a frameshift missense will cause the codons to be out of order, but a substitution missense does not change the order of the codons.
a substitution missense affects only one codon, but a frameshift missense affects all codons downstream of the frameshift.
a frameshift missense mutation will cause an early stop codon, but a substitution missense might be silent.
part d
which of the following sequences shows a frameshift mutation compared to the wild - type mrna sequence?
wild - type 5 - augcauaca uuggaguga - 3
mutant 5 - augcauacguuggaguga - 3

Explanation:

A frameshift mutation alters the reading frame of the mRNA, changing all subsequent codons. This can lead to a non - functional protein or an early stop codon. In contrast, a substitution missense mutation only changes one codon. If the substitution results in a different amino acid, it may or may not significantly affect the protein's function. But a frameshift has a more widespread impact on the amino acid sequence downstream of the mutation site.

Answer:

A frameshift missense mutation will cause the codons to be out of order, but a substitution missense does not change the order of the codons.