Question

10 select the correct word or phrase from each drop - down to accurately indicate when function of proteins is altered as a result of the disease or condition

1. osteogenesis imperfecta - weak or fragile bones caused by a genetic defect in collagen production
2. type ii diabetes mellitus - high blood glucose levels caused by decreased sensitivity to the hormone insulin
3. tetrodotoxin poisoning from a parrotfish exposure - paralyzes muscle due to binding of fast sodium channels
4. phenylketonuria - genetic mutation in an enzyme that catabolizes the amino acid phenylalanine
5. myasthenia gravis - antibodies bind to and attack the bodys own proteins
6. cardiac myopathy - induced by genetic alteration in abnormal myosin production
7. congenital ectodermal dysplasia - defect in desmosomes causing skin that easily separates from deeper layers

Explanation:

1. Osteogenesis imperfecta is due to a defect in collagen structure affecting bone strength.
2. In type II diabetes, the body's communication with insulin (a hormone - protein interaction) is disrupted.
3. Tetrodotoxin binding to sodium channels affects muscle movement as sodium channels are crucial for muscle action potentials.
4. Phenylketonuria is caused by a defect in an enzyme's catalytic function for phenylalanine metabolism.
5. In myasthenia gravis, antibodies interfere with the body's recognition of its own proteins.
6. Cardiac myopathy due to abnormal myosin affects muscle movement in the heart.
7. Congenital ectodermal dysplasia with desmosome defect impacts cell - cell adhesion in the skin.

Answer:

1. Structure
2. Communication
3. Movement
4. Catalysis
5. Recognition
6. Movement
7. Cell Adhesion