question 34

given the following phenotypic reactions, determine the most probable genotype:

anti-d anti-c anti-e anti-c anti-e
0 0 0 + +

---/---
rr
roro
rzrz

Question

question 34

given the following phenotypic reactions, determine the most probable genotype:

anti-d anti-c anti-e anti-c anti-e
0 0 0 + +

---/---
rr
roro
rzrz

Accepted Answer

{ "quality": "clear", "question_count": 1, "skills_matched": [ "step_cot", "multiple_choice_formatter", "explain_then_answer", "tutor", "mastery_adaptive_brevity" ], "needs_drawing": false, "concepts_used": [ "Rh Blood Group System", "Wiener Nomenclature", "Rh Genotype Frequencies" ], "new_concepts": [], "current_concepts": [ "Rh Blood Group System", "Wiener Nomenclature", "Rh Genotype Frequencies" ] } ## Identify the antigens present Using the **Rh Blood Group System** knowledge point $$ \begin{aligned} &\text{Anti-D: } 0 \implies \text{D antigen is absent (d/d)}\ &\text{Anti-C: } 0 \implies \text{C antigen is absent}\ &\text{Anti-E: } 0 \implies \text{E antigen is absent}\ &\text{Anti-c: } + \implies \text{c antigen is present}\ &\text{Anti-e: } + \implies \text{e antigen is present} \end{aligned} $$ ## Determine the phenotype Using the **Rh Blood Group System** knowledge point $$ \text{Phenotype: } \text{D- C- E- c+ e+} \implies \text{ce} $$ ## Translate to Wiener nomenclature Using the **Wiener Nomenclature** knowledge point $$ \begin{aligned} &R^0 \text{ or } R_0 \implies \text{Dce}\ &r \implies \text{dce}\ &R^z \text{ or } R_z \implies \text{DCE} \end{aligned} $$ ## Determine the most probable genotype Using the **Rh Genotype Frequencies** knowledge point $$ \begin{aligned} &\text{Since D, C, and E are absent, the haplotype must be } \text{dce (represented by } r\text{).}\ &\text{Since the individual is homozygous for these absent antigens, the genotype is } rr\text{.} \end{aligned} $$

(A) ---/---

(B) rr

(C) R0R0

(D) RzRz

{ "subject": "Natural Science", "question_type": "Multiple Choice", "knowledge_point": [ "Natural Science", "Biology", "Immunohematology" ] }

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QUESTION IMAGE

Question

Explanation:

Identify the antigens present

Determine the phenotype

Translate to Wiener nomenclature

Determine the most probable genotype

Answer: