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the problem of the stomach that often leads to the deficiency of intrinsic factor and hence to pernicious anemia. chronic atrophic gastritis chronic infectious gastritis adenocarcinoma of the stomach partial gastrectomy
Pernicious anemia is caused by a deficiency of intrinsic factor, which is produced by the parietal cells of the stomach. Chronic Atrophic Gastritis often involves the loss of parietal cells, leading to intrinsic factor deficiency. Chronic Infectious Gastritis (like H. pylori - related) doesn't typically cause intrinsic factor deficiency. Adenocarcinoma of the stomach and Partial Gastrectomy are not the primary causes related to intrinsic factor deficiency leading to Pernicious anemia in the same way as Chronic Atrophic Gastritis.
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A. Chronic Atrophic Gastritis