a person has inherited the following genes:

le/le, se/se

what lewis antibody(ies) could they form?

anti-leb only

none

anti-lea and anti-leb

anti-lea only

Question

a person has inherited the following genes:

le/le, se/se

what lewis antibody(ies) could they form?

anti-leb only

none

anti-lea and anti-leb

anti-lea only

Accepted Answer

{ "quality": "clear", "question_count": 1, "skills_matched": [ "step_cot", "multiple_choice_formatter", "explain_then_answer", "tutor", "mastery_adaptive_brevity" ], "needs_drawing": false, "concepts_used": [ "Lewis Blood Group", "Lewis Antigen Biosynthesis", "Lewis Phenotypes", "Lewis Antibodies" ], "new_concepts": [], "current_concepts": [ "Lewis Blood Group", "Lewis Antigen Biosynthesis", "Lewis Phenotypes", "Lewis Antibodies" ] } ## Determine the inherited phenotype Using the *Lewis Phenotypes* and *Lewis Blood Group* knowledge points $$ \begin{aligned} &\text{Genotype: } Le/Le,\ se/se \ &\text{Lewis Phenotype: } \text{Le}(a+b-) \end{aligned} $$ ## Analyze antigen biosynthesis Using the *Lewis Antigen Biosynthesis* knowledge point $$ \begin{aligned} &Le \text{ gene encodes FUT3 } (\alpha\text{-1,3/1,4-fucosyltransferase}) \ &se/se \text{ genotype lacks functional FUT2 } (\alpha\text{-1,2-fucosyltransferase}) \ &\text{Result: Only } \text{Le}^\text{a} \text{ is synthesized and adsorbed onto RBCs} \end{aligned} $$ ## Evaluate antibody formation potential Using the *Lewis Antibodies* knowledge point $$ \begin{aligned} &\text{Self-antigen present: } \text{Le}^\text{a} \ &\text{Self-antigen absent: } \text{Le}^\text{b} \ &\text{Antibody potential: } \text{Anti-Le}^\text{b} \text{ only (as } \text{Le}^\text{a} \text{ is recognized as self)} \end{aligned} $$

Anti-Leb only

none

Anti-Lea and anti-Leb

Anti-Lea only

{ "subject": "Natural Science", "question_type": "Multiple Choice", "knowledge_point": [ "Natural Science", "Medicine", "Immunohematology" ] }

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QUESTION IMAGE

Question

Explanation:

Determine the inherited phenotype

Analyze antigen biosynthesis

Evaluate antibody formation potential

Answer: