Question

multiple select question
select all that apply
why does erythropoiesis decrease with age?

elderly people tend to get less exercise and eat less well

the bone marrow in the elderly is more sensitive to epo.

gastric atrophy may occur, reducing intrinsic factor secretion.

the kidneys atrophy and produce less epo.

Explanation:

• For "Elderly people tend to get less exercise and eat less well": Poor diet and reduced exercise can impact nutrient intake and physiological stimuli for erythropoiesis, contributing to its decrease.
• For "Gastric atrophy may occur, reducing intrinsic factor secretion": Intrinsic factor is needed for vitamin B12 absorption, which is essential for red blood cell production. Reduced secretion affects erythropoiesis.
• For "The kidneys atrophy and produce less EPO": Erythropoietin (EPO) from kidneys stimulates red blood cell production. Reduced EPO production due to kidney atrophy decreases erythropoiesis.
• The option "The bone marrow in the elderly is more sensitive to EPO" is incorrect as reduced sensitivity (not increased) is typical with age, and increased sensitivity would likely increase, not decrease, erythropoiesis.

Answer:

A. Elderly people tend to get less exercise and eat less well, C. Gastric atrophy may occur, reducing intrinsic factor secretion, D. The kidneys atrophy and produce less EPO