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Question
lock and key
using your notes, fill in the blank and answer the questions below.
1 what is the lock and key model of enzyme action, and how does it explain enzyme specificity?
2 how does the shape of an enzymes active site determine its specificity for a particular substrate? use the lock and key model to support your explanation.
The "lock and key" model of enzyme action posits that enzymes (locks) have specific active sites that fit only certain substrates (keys). Enzyme specificity is explained as only substrates with a complementary shape to the active site can bind. The shape of the active site is like a mold; only the substrate (key) with the matching shape can insert (bind). This geometric complementarity ensures the enzyme acts only on its specific substrate.
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- The “lock and key” model views enzymes as having rigid active sites (locks) that precisely fit specific substrates (keys). Enzyme specificity is due to this unique fit; only the correct - shaped substrate binds.
- The active - site shape is like a lock’s interior. Only a substrate (key) with a complementary shape can bind. For example, if the active site is hexagonal (lock), only a hexagonal - shaped substrate (key) binds, showing specificity based on shape complementarity.