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Question
genetic variation from errors quick check
which type of mutation causes cystic fibrosis? (1 point)
substitution
silent
insertion
deletion
Cystic fibrosis is caused by a deletion mutation. Specifically, in the CFTR gene, there is a deletion of three base pairs which results in the loss of the amino acid phenylalanine. This deletion disrupts the normal function of the CFTR protein. A substitution mutation involves replacing one base with another. A silent mutation does not change the amino acid sequence (so has no functional impact in terms of protein function change in the way cystic fibrosis is caused). An insertion mutation adds extra base pairs.
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deletion