QUESTION IMAGE
Question
- complete the table below comparing the chemistry of amino acids in the wild-type mc1r protein and the mutant mc1r protein.
comparison table
amino acid mutation position number
example 1
wild-type mc1r amino acid chemistry polar (hydrophilic), neutrally charged
mutant mc1r amino acid chemistry electrically charged, negative (acidic)
Step1: Analyze Amino Acid Properties
Wild - type: Polar (hydrophilic), neutrally charged. Common amino acids with this property: e.g., Serine (Ser), Threonine (Thr), Asparagine (Asn), Glutamine (Gln).
Mutant: Electrically charged, negative (acidic). Common acidic amino acids: Aspartic acid (Asp), Glutamic acid (Glu).
Step2: Determine Mutation Logic
A mutation that changes a neutral polar amino acid to an acidic (negatively charged) one. For example, if wild - type is Gln (polar, neutral) and mutant is Glu (acidic, negative), or Asn to Asp. Let's take a common example: Suppose wild - type is Asparagine (Asn) at a position, and mutant is Aspartic acid (Asp)? No, Asp is acidic. Wait, better: Wild - type could be Gln (polar, neutral) and mutant Glu (acidic, negative). Or Asn (polar, neutral) to Asp (acidic, negative). Let's pick a position. Let's assume a position, say position X. Let's use a real - life example: In MC1R mutations, a common mutation is from Asn (polar, neutral) to Asp (acidic, negative) or Gln to Glu. Let's fill the table with an example. Let's say Position Number: Let's pick 50 (arbitrary). Wild - Type MC1R Amino Acid Chemistry: Polar (hydrophilic), neutrally charged (e.g., Asn). Mutant MC1R Amino Acid Chemistry: Electrically charged, negative (acidic) (e.g., Asp). So:
| Amino Acid Mutation Position Number | Wild - Type MC1R Amino Acid Chemistry | Mutant MC1R Amino Acid Chemistry |
|---|
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The table can be completed with an example (here is one possible example):
| Amino Acid Mutation Position Number | Wild - Type MC1R Amino Acid Chemistry | Mutant MC1R Amino Acid Chemistry |
|---|
(Note: The position number can vary, and other amino acids with corresponding chemical properties can be used as long as the wild - type is polar/neutral and mutant is acidic/negative.)