Question

which issue is related to long-term marijuana use?
brain damage
difficulty thinking
mood swings
altered senses

Explanation:

Long - term marijuana use can lead to changes in the brain's structure and function over time, which can result in brain damage. Difficulty thinking, mood swings, and altered senses are more associated with short - term or acute effects of marijuana use. So the issue related to long - term marijuana use is brain damage.

Answer:

A. brain damage