Question

which of the following causes problems in protein synthesis. choose all that apply
tetracycline
aminoglycosides
macrolides
polymyxin

Explanation:

• Tetracycline: Binds to the 30S ribosomal subunit and inhibits the binding of amino - acyl tRNA to the mRNA - ribosome complex, thus interfering with protein synthesis.
• Aminoglycosides: Bind to the 30S ribosomal subunit, cause misreading of the mRNA code, and can also inhibit the initiation of protein synthesis.
• Macrolides: Bind to the 50S ribosomal subunit and inhibit the translocation step of protein synthesis.
• Polymyxin: Acts on the cell membrane (lipopolysaccharide and phospholipid components), not directly on protein synthesis machinery.

Answer:

Tetracycline, Aminoglycosides, Macrolides