Question

take a close look at the three molecules below. which of the following would be water soluble? in other words, which ones can readily form hydrogen bonds? hint: which ones have oh groups? oxycodone morphine heroin

Explanation:

Hydrogen bonding occurs when there is an \( \ce{OH} \) group (as water has \( \ce{OH} \) groups and "like - dissolves - like" in terms of polar interactions). Oxycodone has one \( \ce{OH} \) group, morphine has two \( \ce{OH} \) groups. Heroin has ester (\( \ce{R - COO - R'} \)) groups instead of \( \ce{OH} \) groups. The more \( \ce{OH} \) groups (polar groups that can hydrogen - bond with water), the more likely the molecule is to be water - soluble.

Answer:

Oxycodone, Morphine.